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KMID : 0363620190400020094
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Journal of Korean Oriental Medicine
2019 Volume.40 No. 2 p.94 ~ p.105
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Cardiac Safety Assessment of Medicinal Herbal Formulas Using hERG-HEK 293 cell
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Choi Susanna
Kwon Oh-Bin
Lee Si-On
Seo Chang-Seob
Shin Hyeun-Kyoo
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Abstract
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Objectives: The correlation between medicinal herbal formulas and a risk of cardiotoxicity has been controversial. Thus, this study investigated cardiac safety assessment of 52 most commonly used medicinal herbal formulas.
Methods: We evaluated the in vitro effects of medicinal herbal formulas on recombinant human embryonic kidney 293 (HEK 293) cell line expressing human ether-a-go-go-related gene (hERG) potassium channel.
Results and Conclusion: Our results demonstrated that all of 52 medicinal herbal formulas did not show inhibition of hERG current in hERG-HEK 293 recombinant cells. In conclusion, these safety data suggest that 52 medicinal herbal formulas were not associated with an increased risk of cardiotoxicity in hERG-HEK 293 recombinant cells.
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KEYWORD
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Medicinal herbal formulas, Korea traditional medicine, cardiac safety, cardiotoxicity, hERG potassium channel
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